Antiulcer Activity of Aloe vera in Aspirin-Induced Mice

Abstract

Gastric ulcers often characterized by the destruction of the mucosal to muscularislayer of the stomach. One of its major etiology is prolonged NSAIDs use. Its incidence is increasing every year, and often disrupt patients’ quality of life. Aloe vera is empirically used as antiulcer in Indonesia, therefore this study was aimed to determine its activity in aspirin induced male-swiss-mice, with ranitidine as comparator. Methods :Thirty mice were randomized and divided into 6 groups : Negative control, positive control, comparison group (given ranitidine with dose 1,4 mg/20 g), Aloe vera juice group 0,1 ml/20g, 0,3 ml/20g and 0,6 ml/20g. All treatment were administered orally followed by 16.8 mg/20g bw aspirin administration, once a day for three days. Observed parameters including the number and diameter of the ulcer. The results of protection percentage were analyzed statistically using Kruskall Wallis test (α = 0,05), then continued with Post Hoc test. Results :Aloe vera 0.3 ml/20g and 0.6 ml/20g bwpossesed a gastric anti-ulcer activity by decreasing number of ulcers in aspirin induced male-swiss-mice significant to control group (p<0.05)..Conclusion :This study propose a potential antiulceractivity of aloe vera. Further research is needed to propose its mechanism of action.