HEPATOPROTECTOR ACTIVITY TEST OF GREEN TEA (Camellia sinensis, L) GAMBUNG VARIETY ETHANOL EXTRACT IN BALB/C MOUSE INDUCED WITH CCL4

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Published: Dec 10, 2021
Keywords:
ethanol extract green tea leaf hepatoprotector

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Ani Riyani
Politeknik Kesehatan Kemenkes Bandung
M. Firman Solihat
Politeknik Kesehatan Kemenkes Bandung
Dadan Rohdiana
Balai Penelitian Teh dan Kina Gambung

Abstract

Background: Green Tea Leaves (Camellia sinensis, L) are widely used for various daily needs and have been widely researched and developed. Green tea contains active compounds of flavonoids, alkaloids, terpenoids, polyphenols and saponins. Extraction of tea leaves was carried out by maceration using ethanol as a solvent, after phytochemical tests were found to contain alkaloids, saponins and flavonoids. Flavonoids are the largest group of phenolic compounds which have effective properties to inhibit the growth of viruses and bacteria. Tea leaves are known to contain polyphenols which have the potential as hepatoprotectors. Methods: The research method used is a laboratory experiment. This study aims to determine the hepatoprotective activity of the ethanolic extract of green tea leaves against Balb/C mice with CCl4 induction and by observing the activity of the enzymes AST, ALT, ALP, GGT, and MDA levels.


Result: The results showed that there was significant hepatoprotective activity tested by the one-way Anova test with a 95% confidence level (α = 0.05) with a dose of green tea leaf ethanol extract starting at 50 mg/100 mL.


Conclusions: Green tea leaf ethanol extract starting at 50 mg/kg BW gave good results as a hepatoprotector in CCl4-induced Balb/c mice. by analyzing the enzyme activity of ALT, AST, ALP, GGT and MDA levels 

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Issue
Vol. 3 No. 1 (2021): Proceeding of The 4th International Conference on Interprofessional Health Collaboration and Community Empowerment
Section
Proceeding

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